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Multiscale modeling is becoming essential for accurate, rapid simulation in science and engineering. This book presents the results of three decades of research on multiscale modeling in process engineering from principles to application, and its generalization for different fields. This book considers the universality of meso-scale phenomena for the first time, and provides insight into the emerging discipline that unifies them, meso-science, as well as new perspectives for virtual process engineering.
Multiscale modeling is applied in areas including:
Jinghai Li is Vice-President of the Chinese Academy of Sciences (CAS), a professor at the Institute of Process Engineering, CAS, and leader of the EMMS (Energy-minimizing multiscale) Group.
Wei Ge, Wei Wang, Ning Yang and Junwu Wang are professors at the EMMS Group, part of the Institute of Process Engineering, CAS.
Xinhua Liu, Limin Wang, Xianfeng He and Xiaowei Wang are associate professors at the EMMS Group, part of the Institute of Process Engineering, CAS.
Mooson Kwauk is an emeritus director of the Institute of Process Engineering, CAS, and is an advisor to the EMMS Group.
Particulate discrete element analysis is becoming increasingly popular for research in geomechanics as well as geology, chemical engineering, powder technology, petroleum engineering and in studying the physics of granular materials. With increased computing power, practising engineers are also becoming more interested in using this technology for analysis in industrial applications. This is the first single work on Discrete Element Modelling (DEM) providing the information to get started with this powerful numerical modelling approach.
Written by an independent author with experience both in developing DEM codes and using commercial codes, this book provides the basic details of the numerical method and the approaches used to interpret the results of DEM simulations. Providing a basic overview of the numerical method, Particulate Discrete Element Modelling discusses issues related to time integration and numerical stability, particle types, contact modelling and boundary conditions. It summarizes approaches to interpret DEM data so that users can maximize their insight into the material response using DEM. The aim of this book is to provide both users and prospective users of DEM with a concise reference book that includes tips to optimize their usage.
Particulate Discrete Element Modelling is suitable both for first time DEM analysts as well as more experienced users. It will be of use to professionals, researchers and higher level students, as it presents a theoretical overview of DEM as well as practical guidance on running DEM simulations and interpreting DEM simulation data.
The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens?
Written from the industry perspective and based on many years of experience, this book offers:
- Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs
- Guidance for exploration and modification of these programs to enhance the understanding of key principles
- Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature
- A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling.
Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.
This elegant volume offers itself as a spiritual companion for young adults and all who live amid transitions and tensions.
Dozens of carefully selected readings address themes that are prominent for people in their twenties and early thirties. The topics include:
Each section features reflections from Unitarian Universalist young adults, as well as poems, prayers, and opening and closing words from contemporary and ancient peoples. This treasury of uplifting and thought-provoking meditations can serve as a guide and provide comfort on our never-ending journey of becoming.
To compete in today's volatile market with rapidly changing consumer tastes and erce competition, companies in the manufacturing and service industries are - ploying new mechanisms to increase sales, market shares, and pro ts. As an - fective mechanism to segment a market comprising of consumers with different needs, preferences, and willingness-to-pay, many rms have used product (or s- vice) variety with different price points to serve different segments of the market, see Ho (1998). Ideally, the price of each of these products (or services) targets a particular segment of customers. For example, airlines often use different terms of sales (refundable/non-refundable, upgradable/non-upgradable, direct/connecting ight, etc. ) to sell economy class tickets at different prices. Likewise, retailers - ten sell the same product at different prices in different channels (company's own web site, dealers' web sites, or company's physical stores) or at different times (- fore, during, and after the selling season), see Talluri and van Ryzin (2005). Ample academic literature in Operations Management and other areas considered these strategies. However, as consumers become more knowledgeable about the product, pricing, organizational and operational policies that the companies deploy for pr- ucts and services, their purchasing begins to change dramatically. In the academic Operations Management literature, consumer demand is often assumedtobe exogenous so that demand functions are usually modeled as well de- ned and exogenously speci ed functions of price and/or other product attributes such as quality.
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