An autobiography of a ground-breaking medical doctor. Dr. David A. Hamburg started as a medical student with interest in stress disorders, paying special attention to the propensity toward violence, including the evolution of human aggression. This lead him on a path to becoming one of the most highly celebrated doctors in America - he was a member of President Clinton's Committee of Advisors on Science and Technology and was awarded the Presidential Medal of Freedom (the highest civilian award of the United States). Most recently, he chaired committees at the United Nations and European Union on the prevention of genocide. This book will be inspirational for emerging scientists today.
The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers: - Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs - Guidance for exploration and modification of these programs to enhance the understanding of key principles - Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature - A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling. Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.
Multiscale modeling is becoming essential for accurate, rapid simulation in science and engineering. This book presents the results of three decades of research on multiscale modeling in process engineering from principles to application, and its generalization for different fields. This book considers the universality of meso-scale phenomena for the first time, and provides insight into the emerging discipline that unifies them, meso-science, as well as new perspectives for virtual process engineering.
Multiscale modeling is applied in areas including:
Jinghai Li is Vice-President of the Chinese Academy of Sciences (CAS), a professor at the Institute of Process Engineering, CAS, and leader of the EMMS (Energy-minimizing multiscale) Group.
Wei Ge, Wei Wang, Ning Yang and Junwu Wang are professors at the EMMS Group, part of the Institute of Process Engineering, CAS.
Xinhua Liu, Limin Wang, Xianfeng He and Xiaowei Wang are associate professors at the EMMS Group, part of the Institute of Process Engineering, CAS.
Mooson Kwauk is an emeritus director of the Institute of Process Engineering, CAS, and is an advisor to the EMMS Group.
Cartographies of becoming in education: A Deleuze-Guattari Perspective proposes a non-hierarchical approach that maps teaching and learning with the power of affect and what a body can do/become in different educational contexts. Teaching and learning is an encounter with the unknown and happen as specific responses to particular problems encountered with/in life. In this edited volume, international scholars map out potential ruptures in teaching and learning in order to conceptualize education differently. One way is through the multidisciplinary lens of MLT (Multiple Literacies Theory) in which reading is intensive and immanent. The authors deploy different aspects of MLT while creating and experimenting with ethology, teaching, learning, curriculum, teacher education and technology in relation to visual arts, music, mathematics, theatre, workplace literacy, second language education, and architecture. With the forces of globalization, digital media and economic re-structuring reconfiguring the social, political and economic landscape, societies require innovative ways of thinking about education. Cartographies of becoming in education: A Deleuze-Guattari Perspective is a response to problems posed by such forces. The problematic surrounding Deleuze-Guattari and education continues to grow. Diana Masny's scholarship in this area is well known and appreciated through her many essays and books that develop MLT (Multiple Literacies Theory). Cartographies of Becoming in Education: A Deleuze-Guattari Perspective continues her effort to broaden the notion of education and show its intersections with MLT. The series of essays do this by forming a number of 'entries, ' five to be precise: politicizing education, affect and education, literacies and becoming, teacher-becomings, and deterritorializing boundaries. Each 'entry' explores the way an MLT inflected orientation enables us to further grasp the creative inventiveness of the Deleuze-Guattarian tool kit that can be applied to areas of music education, ethnography, art, drama, literacy, mathematics, landscape ecology, ethology and teacher education. It is a vivid illustration of the cartography that maps the rhizomatic movements that are taking place by international scholars who are deterritorializing education as a discipline of modernity. I highly recommend this collection of essays to those of us who are continually asking how might education be rethought through the unthought. It opens up new territories. - Jan Jagodzinski, University of Alberta, Author of Psychoanalyzing Cinema.
This book is a textbook (it includes, for example, exercises and outline solutions). The plant scientist is shown how to express physiological ideas mathematically and how to deduce quantitative conclusions, which can then be compared with experiment. There is little new biology in the book, but it is presented in a way that will be new to many biologists. The matching of models to experiments means using mathematics for formulating biological concepts and second, using algebra, calculus, or, now more frequently, computers to solve or simulate the resulting model; and finally, comparing, qualitatively or quantitatively, prediction to measurement. Computers are the important enabling technology that makes it all possible: solving equations, assembling models of increasing sophistication and complexity, and comparing theory with experiment. The book is divided into three parts. Part I. Covers subjects of wide relevance to modelling and plant biology. Part II. The reader may choose to select topics of particular interest from part II. However, the whole-plant modeller will need to study all chapters, and the plant ecosystem modeller may need to add other material also. Part III. Plant morphology is at an introductory level. It is included because morphological characters may prove to be of equal importance to some physiological traits in determining plant function and performance. "This textbook presents, in an interesting and clearly written fashion, a mathematical approach to a wide range of topics in plant and crop physiology, including light interception, leaf and canopy photosynthesis, respiration, partitioning, transpiration and water relations, branching and phyllotaxis. The biochemistry of plant growth and maintenanace is also presented in some detail. I was very pleased with the text, especially with the philosophy presented by the authors that biological models are necessarily simplifications of complex detail. I would strongly recommend it for reading and consultation by graduates and research workers." J. Exp. Botany "The authors' approach succeeds admirably, giving a thorough account of the mathematical toolbox available to researchers and the areas in which those tools have been used." Plant, Cell and Environment "Combining considerable technical cleverness with creativity and the refreshing notion that science is a "common-sense, unpredictable, fascinating and thoroughly human activity." Times Higher Educational Supplement "Exceptionally scholarly volume. Logical and systematic. Authors have assembled a mass of mathematical material in an elegant layout." Agricultural Systems
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