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A step-by-step guide to using computational tools to solve problems in cell biology <p> Combining expert discussion with examples that can be reproduced by the reader, <i>A Cell Biologist's Guide to Modeling and Bioinformatics</i> introduces an array of informatics tools that are available for analyzing biological data and modeling cellular processes. You learn to fully leverage public databases and create your own computational models. All that you need is a working knowledge of algebra and cellular biology; the author provides all the other tools you need to understand the necessary statistical and mathematical methods. <p> Coverage is divided into two main categories: <ul> <li>Molecular sequence database chapters are dedicated to gaining an understanding of tools and strategies—including queries, alignment methods, and statistical significance measures—needed to improve searches for sequence similarity, protein families, and putative functional domains. Discussions of sequence alignments and biological database searching focus on publicly available resources used for background research and the characterization of novel gene products. <li>Modeling chapters take you through all the steps involved in creating a computational model for such basic research areas as cell cycle, calcium dynamics, and glycolysis. Each chapter introduces a new simulation tooland is based on published research. The combination creates a rich context for ongoing skill and knowledge development in modeling biological research systems. </ul> <p> Students and professional cell biologists can develop the basic skills needed to learn computational cell biology. This unique text, with its step-by-step instruction, enables you to test and develop your new bioinformatics and modeling skills. References are provided to help you take advantage of more advanced techniques, technologies, and training.
Coupled climate system models are of central importance for climate studies. A new model known as FGOALS ( the Flexible Global Ocean-Atmosphere-Land System model), has been developed by the Sate Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences (LASG/IAP, CAS), a first-tier national geophysical laboratory. It serves as a powerful tool, both for deepening our understanding of fundamental mechanisms of the climate system and for making decadal prediction and scenario projections of future climate change. "Flexible Global Ocean-Atmosphere-Land System Model: A Modeling Tool for the Climate Change Research Community is the first book to offer systematic evaluations of this model s performance. It is comprehensive in scope, covering both developmental and application-oriented aspects of this climate system model. It also provides an outlook of future development of FGOALS and offers an overview of how to employ the model. It represents a valuable reference work for researchers and professionals working within the related areas of climate variability and change. Prof. Tianjun Zhou, Yongqiang Yu, Yimin Liu and Bin Wang work at LASG, the Institute of Atmospheric Physics, Chinese Academy of Sciences, China."
This research monograph is an empirical examination of cultural influences on judgments of professional accountants from Australia, India and Malaysia in relation to a number of ethical issues in accounting including auditor-client conflict resolution, whistle blowing as an internal control mechanism and social desirability response bias. The study informs and guides both the theoretical specification and treatment of culture and its operationalization and methodology. It is shown that enhancement in the quality of cross-cultural research in accounting can be accomplished by providing greater insight into the depth, richness and complexity of cultural similarities and differences between and across nations by complementing the quantified dimensional based cultural measures with relevant historical, sociological and psychological literature. The findings of the study have implications for the management of multinational enterprises, the international convergence and harmonisation of accounting and auditing standards, and for cross-cultural accounting research. This research monograph would be particularly useful for researchers and research students interested in international dimensions of accounting and in ethical issues in international business.
This is an engaging study of the mental lexicon - the way in which the form and meaning of words is stored by speakers of specific languages. Fortescue attempts to narrow the gap between the results of experimental neurology and the concerns of theoretical linguistics in the area of lexical semantics. The prime goal as regards linguistic theory is to show how matters of lexical organization can be analysed and discussed within a neurologically informed framework that is both adaptable and constrained. It combines the perspectives of distributed network modelling and linguistic semantics, and draws upon the accruing evidence from neuroimaging studies as regards the cortical regions involved. It engages with a number of controversial current issues in both disciplines. This text is intended as a tool for linguists interested in psychological adequacy and the latest advances in Cognitive Science. It provides a principled means of distinguishing those semantic features required by a mental lexicon that have a direct bearing on grammar from those that do not. "A Neural Network Model of Lexical Organisation" is essential reading for researchers in neurolinguistics and lexical semantics. "Continuum Studies in Theoretical Linguistics" publishes work at the forefront of present-day developments in the field. The series is open to studies from all branches of theoretical linguistics and to the full range of theoretical frameworks. Titles in the series present original research that makes a new and significant contribution and are aimed primarily at scholars in the field, but are clear and accessible, making them useful also to students, to new researchers and to scholars in related disciplines.
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